Scientific Publications

Cao P, Chang D-K, Rakestraw A, Shaw A, Pucci F, Fachin F, McInnis C, Carey S, Boesch A, Chirgwin D, Tassa C, Handler A, Jones K, Bardwell P, Geretti E, Liang X, Nardozzi J, Jones D, Lyons J, Fitzgerald JB, Hewes B, Nielsen UB, Andresen, TL. Deep™ IL-15 provides autocrine stimulation and expansion of autologous T cells driven by controlled concentrated release of IL-15. AACR Annual Meeting 2018, April 17, 2018.

Nardozzi J, Geretti E, Chang D-K, McMillin DW, Lyons J, Nielsen U, Andresen T, Jones D. Cell therapy with surface-tethered IL-12 provides immune system priming and strong anti-tumor activity. AACR Annual Meeting 2018, April 17, 2018.

Fichter M, Tang L, Zheng Y, Melo M, Li N, Irvine D. T cell receptor signaling-responsive single chain IL-12 and IL-15 superagonist nanogel ‘backpacks’ to enhance adoptive cell therapy in solid tumors. AACR Annual Meeting 2018, April 17, 2018.

Jones RB, Mueller S, Kumari S, Vrbanac V, Genel S, Tager AM, Allen TM, Walker BD, Irvine DJ. Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells. Biomaterials (2016) 117:44-53

Stephan MT, Stephan SB, Bak P, Chen J, Irvine DJ. Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles. Biomaterials (2012) 33(23):5776-5787.

Stephan MT, Moon JJ, Um SH, Bershteyn A, Irvine DJ. Therapeutic cell engineering with surface-conjugated synthetic nanoparticles. Nat. Med. (2010). 16(9):1035-1041.

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